Pauline

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Date registered: May 14, 2011

Latest posts

  1. Paddling Outrigger Canoe in Hawaii — October 21, 2019
  2. FDA Validation of Companion Diagnostic (PCR test) — November 27, 2018
  3. Creating Your Own Personal Silent Retreat — September 1, 2018
  4. Fantasy and Genetics – Do They Go Together Like Science and Fiction? — June 12, 2018
  5. Obsessions in Alzheimer’s — April 2, 2018

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Oct
21

Paddling Outrigger Canoe in Hawaii

Singapore waters are warm all-year-round, so even on Christmas day we can paddle. However, Singapore lacks waves (except for those generated by the occasional ferry passing by). I love the rush from surfing waves — you feel like you’re flying. So a year ago, my partner asked for an OC paddling vacation to surf waves.  …

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Nov
27

FDA Validation of Companion Diagnostic (PCR test)

I’ve been helping get a companion diagnostic get approved as a FDA test. This blog series will describe the statistics (R) used for the FDA validation of the companion diagnostic. The companion diagnostic test is a PCR test to check for a fusion / rearrangement on the customer’s DNA. Normally, people have gene A and …

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Sep
01

Creating Your Own Personal Silent Retreat

I was seeking silence and solitude so I spent a few days at Bali Silent Retreat. It was an ascetic vegetarian lifestyle (which was a bit much for me). While I had my moments of revelation, I realized I didn’t have to fly to Indonesia for silence. This blog post will describe how to create …

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Jun
12

Fantasy and Genetics – Do They Go Together Like Science and Fiction?

This could be a disaster. I’m launching a new website that does genetic analyses for fun. It combines make-believe and science. There are a lot of direct-to-consumer genetics products out there, yet genetics is not very predictive at the individual level. The science behind these difficulties is abtruse, so why not have some fun while helping people understand …

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Apr
02

Obsessions in Alzheimer’s

This video shows a woman with Alzheimer’s who is obsessed with finding and helping a non-existent cat. The obsession happens over a two-month period and you can tell she’s very distressed. She is always looking for a cat — wandering the streets and even breaking windows to go out and find this cat. Her daughter …

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Dec
27

Can’t lose weight with Belviq?

With the holidays nearly over, I have to admit I’m feeling sick overeating with the holiday parties and goodies given as gifts. We’ll be examining the gender differences in the weight loss drug Belviq (generic name lorcaserin). Based on online ratings, Belviq works better in males than in females (men gave 1.18 more points for …

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Dec
24

Treating depression: Wellbutrin is more effective for females than males.

Millions suffer from depression, so it’s important to know which treatments work. Women are underrepresented in clinical trials. Thus, it is possible that they react differently to drugs. To study this, we downloaded online drug reviews to see if women responded to drugs differently than men. Surprisingly, women rated Wellbutrin XL higher than males. Wellbutrin …

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Sep
27

Lighting a Path Forward

About 2 years ago, I accidentally wrote a children’s book. (Accidentally is a strange word: rather, I never intended to write a children’s book, but when an idea sticks with me, the only way to get it out of my head is to do it.) My significant other is part of a company that makes …

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Jul
23

There’s No Glass Ceiling if you Leave the Room

My friends have been asking me why I resigned from my current job, with no job lined up. It started when ants found their way into our home. I could see a solid trail of ants determinedly racing towards a destination (turns out someone had spilled soda underneath the fridge). The ants looked something like …

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Jul
10

Reverse engineering contingency (2×2) table from Odds Ratio (OR)

Given the odds ratio (OR), we will calculate the individual cells in the contingency table (a,b,c,d). In yellow, I’ve highlighted what is known. a,b,c, and d are unknown and what we want to calculate. Odds Ratio = (a/c) / (b/d) Cases Controls Total Exposed a b total_exposed (a+b) Unexposed c d total_unexposed(c+d) Total total_cases(a+c) total_controls(b+d) …

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